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. 2020 Jul 24;202(2):137–143. doi: 10.1111/cei.13492

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© 2020 The Authors. Clinical & Experimental Immunology published by John Wiley & Sons Ltd on behalf of British Society for Immunology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Fig. 3 — Analysis of cytosine 5‐hydroxymethylation in selected loci in saliva DNA derived from Sjögren’s syndrome (SS) patients compared to sicca controls by DNA immunoprecipitation followed by quantitative real‐time polymerase chain reaction (PCR). (a) Small increase is observed in the H19 imprinting control region (ICR). (b) Increased 5‐hydroxymethyl cytosine in the long interspersed nuclear element (LINE1) locus of SS patients versus sicca controls. (c) The histone cluster 1 H3 family member b (HIST1H3B) locus (encoding histone H3.1) was used as a control for the immunoprecipitation.