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. 2020 Oct 27;8:e10141. doi: 10.7717/peerj.10141

Table 4. The list of the identified hub protein-coding genes in PDAC.

Gene symbol Node degree Gene name
FN1 25 Fibronectin type III domain containing
TIMP1 23 Tissue inhibitor of metalloproteinases 1
MSLN 22 Pre-pro-megakaryocyte-potentiating factor
FBN1 20 Fibrillin 1
ALB 20 Serum albumin
F5 20 Coagulation factor V (proaccelerin, labile factor)
SERPINA1 20 Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
COL1A2 20 Collagen alpha-2(I) chain
IGFBP3 19 Insulin-like growth factor binding protein 3
COL3A1 19 Collagen alpha-1(III) chain
COL1A1 19 Collagen alpha-1(I) chain
ITGA2 18 Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
COL17A1 18 180 kDa bullous pemphigoid antigen 2
TNC 18 Glioma-associated-extracellular matrix antigen
SPP1 18 Secreted phosphoprotein 1
VCAN 17 Chondroitin sulfate proteoglycan core protein 2
MATN3 17 Matrilin 3
IGFBP5 17 Insulin-like growth factor binding protein 5
EGF 16 Pro-epidermal growth factor
GNB4 16 Guanine nucleotide binding protein (G protein)
LTBP1 16 Latent transforming growth factor beta binding protein 1
COL4A2 16 Collagen alpha-2(IV) chain
LGALS1 16 Lectin, galactoside-binding, soluble, 1
APOL1 16 Apolipoprotein L, 1
COL11A1 16 Collagen alpha-1(XI) chain
ANXA1 16 Phospholipase A2 inhibitory protein
CP 16 Ceruloplasmin (ferroxidase)