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Activity profiles of stereoisomers 6a–d
| Compound | Ca assay IC50 (nM) | Fusion assay pIC50 | |
|---|---|---|---|
| 1 | 94 | 6.07 | |
| 2 | 28 | NDa | |
| 3 | 84 | 6.64 | |
| 4 | 53 | 8.11 | |
| 5 | 13 | 7.06 | |
| 6a(3R, 1’R) |  |
34 | 8.25 |
| 6b(3R, 1’S) |  |
44 | 6.74 |
| 6c(3S, 1’R) |  |
470 | 6.42 |
| 6d(3S, 1’S) |  |
51 | 6.35 |
ND : Not determined.
