Table 2.
P450 inhibition of 1–5 and 6a–d
| Compound | P450 inhibition IC50 (μM) |
||
|---|---|---|---|
| 2C9 | 2D6 | 3A4 | |
| 1 | 5.9 | 4.6 | 19.7 |
| 2 | 5.5 | 7.8 | 9.3 |
| 3 | >30 | >30 | >30 |
| 4 | 3.7 | 9.8 | >30 |
| 5 | 8.8 | >30 | 24.9 |
| 6a | >30 | >30 | >30 |
| 6b | 18 | >30 | >30 |
| 6c | >30 | >30 | >30 |
| 6d | >30 | >30 | >30 |
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