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. Author manuscript; available in PMC: 2020 Oct 30.

Published in final edited form as: Bioorg Med Chem Lett. 2010 Dec 28;21(4):1141–1145. doi: 10.1016/j.bmcl.2010.12.109

Table 3.

Pharmacokinetic profiles of 6a–d

Compound	10 mg/kg, po				3 mg/kg, iv
Compound	C_max (ng/mL)	T_1/2 (min)	AUC (ng h/mL)	BA (%)	AUC (ng h/mL)	T_1/2 (min)	CL (mL/min/kg)	V_ss (mL/kg)
1	33.3^a	75.7	96.7^a	1.3	372	13	137	2349
2	5.6^a	103	24.8^a	1.9	400	19.9	113	2542
5	2400	48.4	10532	34	3091	11.1	16	145
6a (3R, 1′R)	2360	120	3422	23	4402	21.8	11.3	132
6b (3R, 1′S)	70	35.2	67.5	ND^b	ND^b	ND^b	ND^b	ND^b
6c (3S, 1′R)	280	14.4	126	ND^b	ND^b	ND^b	ND^b	ND^b
6d (3S, 1′S)	260	19.2	213	6.5	988	16.2	50.9	836

^a

C_max and AUC are normalized to a dose of 10 mg/kg.

^b

ND: Not determined.