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Anti-HIV activity of the representative compounds
| Compound | Anti-HIV-1 activity IC50 (nM)a |
|
|---|---|---|
| HIV-1Ba-L (R5) | HIV-1MM (R5MDR) | |
| 6a | 0.4 ± 0.3 | 0.6 ± 0.2 |
| TAK-779 | 28 ± 32 | 14 ± 8 |
| SCH-351125 | 4 ± 2 | 3 ± 0.5 |
| Zidovudineb | 7 ± 4 | 250 ± 98 |
| Nelfinavirc | 12 ± 8 | >1000 |
IC50 values are based on the inhibition of HIV p24 antigen expression in PBMC.
Zidovudine is a reverse transcriptase inhibitor.
Nerfinavir is a HIV-1 protease inhibitor
