Table 1:
Baseline characteristics
| Mesenchymal stromal cell group (n=40) | Placebo group (n=20) | |
|---|---|---|
| Patients’ characteristics | ||
| Age (years) | 55 (17) | 55 (20) |
| Men/women | 23 (58%)/17 (42%) | 10 (50%)/10 (50%) |
| Cause of ARDS | ||
| Sepsis with pneumonia | 19 (48%) | 12 (60%) |
| Sepsis without pneumonia | 5 (13%) | 2 (10%) |
| Pneumonia without sepsis | 11 (28%) | 5 (25%) |
| Aspiration only | 4 (10%) | 1 (5%) |
| Other | 1 (3%) | 0 |
| Arterial pressure (mm Hg) | 75 (10) | 76 (9) |
| Taking vasopressors at the time of infusion | 24 (60%) | 9 (45%) |
| SOFA score | 8·1 (3·3) | 6·9 (2·7) |
| APACHE III score | 104 (31) | 89 (33) |
| Respiratory characteristics | ||
| Minute ventilation (L/min) | 11·1 (3·2) | 9·6 (2·4) |
| Respiratory rate (breaths/min) | 27·8 (6·6) | 24·5 (6·3) |
| Tidal volume (mL/kg PBW) | 6·3 (0·9) | 6·1 (0·7) |
| Mean airway pressure (cm H2O) | 17·8 (4·9) | 16·4 (3·6) |
| Plateau airway pressure (cm H2O) | 26·4 (5·7) | 23·7 (5·1) |
| PEEP (cm H2O) | 12·4 (3·7) | 10·8 (2·6) |
| Driving pressure (cm H2O) | 14·0 (4·1) | 12·5 (4·3) |
| PaO2:FiO2 (kPa) | 18·1 (4·3) | 19·1 (5·2) |
| Oxygenation index (kPa)* | 98·7 (78·1–123·3) | 95·6 (71·6–113·8) |
| Lung injury score | 3·1 (00·4) | 3·0 (0·5) |
| Ventilation mode | ||
| Volume control | 37 (93%) | 17 (85%) |
| Pressure-regulated volume control | 1 (3%) | 2 (10%) |
| Other | 2 (5%) | 1 (5%) |
Data are n (%), mean (SD), or median (IQR); percentage values might not sum 100% due to rounding. ARDS=acute respiratory distress syndrome; SOFA=sequential organ failure assessment. APACHE III=Acute Physiology and Chronic Health Evaluation III score. PBW=predicted bodyweight. PEEP=positive end-expiratory pressure. PaO2:FiO2=ratio of partial pressure of oxygen to fractional inspired oxygen. Oxygenation index=FiO2 × mean airway pressure / PaO2.
*
Unavailable for three patients in the mesenchymal stromal cell group and one in the placebo group because mean airway pressure was not recorded.