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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Neurobiol Dis. 2020 Sep 2;145:105064. doi: 10.1016/j.nbd.2020.105064

Fig. 7.

Fig. 7.

Repetitive and exploratory behavior are altered by DLaN. Grooming and movement was assessed in a novel arena from mice of each genotype (Cntnap2 KO, WT) under each lighting condition (LD, DLaN) and the resulting data analyzed with 2-way ANOVA. Histograms show means ± SEM with the values from individual animals overlaid. Significant (P < 0.05) differences because of treatment are indicated with an asterisk (*) over the treated values while the number sign (#) indicates a genotypic difference. (A) Grooming behavior was significantly increased by genotype (F(1,43) = 21.986, P < 0.001) and treatment (F(1, 43) = 8.231, P = 0.007). There was a significant interaction between the two factors (F(1, 43) = 5.296, P = 0.027). (B) Novel arena exploration was decreased by the treatment (F(1, 43) = 5.846, P = 0.020) but not genotype (F(1,43) = 3.603, P = 0.065). (C) The time spent in the center of the open field did not vary with genotype (F(1, 29) = 0.254, P = 0.619 or treatment (F(1,29) = 1.688, P = 0.205). There was no significant interaction between the two factors (F(1, 29) = 0.981, P = 0.331).