Table 3.
DLaN impacted social and grooming behavior.
| Cntnap2 KO | Cntnap2 KO + DLaN | WT | WT + DLaN | Genotype | Treatment | |
|---|---|---|---|---|---|---|
| Three chambered social test | ||||||
| Center chamber (sec) | 153.9 ± 19.1 | 163.6 ± 19.7 | 154.5 ± 15.4 | 144.8 ± 13.3 | F = 0.265; P = 0.610 | F = 0.001; P = 0.999 |
| Social chamber (sec) | 231.2 ± 26.3.6 | 164.4 ± 15.8* | 271.3 ± 15.1 | 236.6 ± 16.8 | F = 8.066 P = 0.008 | F = 6.669; P = 0.014 |
| Object chamber (sec | 218.6 ± 13.8 | 283.0 ± 22.9* | 166.8 ± 11.7 | 218.6 ± 13.8 | F = 8.111; P = 0.008 | F = 9.326; P = 0.004 |
| Social Index | 0.02 ± 0.09 | −0.26 ± 0.07* | 0.24 ± 0.5 | 0.04 ± 0.06* | F = 11.757; P = 0.002 | F = 13.892; P < 0.001 |
| Grooming | ||||||
| Grooming (sec) | 26.7 ± 2.0 | 66.0 ± 14.2* | 8.6 ± 1.7 | 13.7 ± 1.8 | F = 21.986; P < 0.001 | F = 8.231; P = 0.007 |
| Distance (m) | 47.1 ± 3.1 | 38.1 ± 2.0 | 39.4 ± 2.3 | 34.6 ± 1.8 | F = 3.603; P = 0.065 | F = 5.846; P = 0.020 |
Two-way ANOVA followed by Holm-Sidak’s multiple comparisons test was used to evaluate the effects of genotype and time, and their interaction. Degrees of freedom are reported in parentheses. Data are reported as the mean ± SEM. P values < 0.05 were considered significant and are shown in bold.