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. Author manuscript; available in PMC: 2020 Oct 30.
Published in final edited form as: Leukemia. 2020 Jan 27;34(7):1816–1827. doi: 10.1038/s41375-020-0710-7

Figure 5.

Figure 5.

p53 mutation causes a reduction of p53 recruitment at both p21 and GADD45A promoters and leading to a decrease of histone acetylation at these regions.

(A) Top: Diagram representation of p21 promoter. p53 distal and p53 proximal are two p53 binding site on p21 promoter, TSS represents for transcription start site. Middle and bottom: ChIP for p53 and ac-H3 in MV4–11 and MV4–11 R4 cells at p21 promoter region. (B) Top: Diagram representation of GADD45A promoter. Bottom: ChIP for p53 and ac-H4 at GADD45A promoter region. Bars indicate the standard error of mean. *P<0.05 compared to parental cell group.