Figure 3. Kinetics of T cell subsets during H1N1 infection.

(A) Relative abundances of total (left) and activated (CD38⁺Ki67⁺, right) CD4⁺ T cells, naive CD4⁺ T cells (CD45RA⁺), and memory CD4⁺ T cells (CD45RA^–). (B) Relative abundances of total (left) and activated (CD38⁺Ki67⁺, right) CD8⁺ T cells, naive CD8⁺ T cells (CD45RA⁺CD27⁺), and memory CD8⁺ T cells (CD45RA^–CD27⁺). (C) Representative biaxial plots showing the extent of CD38 and Ki67 expression on CD4⁺ and CD8⁺ T cells at days 1, 4, and 8 for a representative virus shedder. In B and C, values plotted are relative abundance (percentage of CD66^– cells normalized to baseline [average of day –1, 1]) (mean ± SEM); filled squares and solid lines indicate virus shedders, and open squares and dashed lines indicate virus nonshedders. (A and B) n = 35 volunteers. Bonferroni’s adjusted P value of the time-shedding interaction term. For plots of additional gated cell populations, see Supplemental Figure 6.