Figure 1. Heterogeneous spectrum of hyperinflammation in Kawasaki syndrome.

Disease model proposes that the magnitude or kinetics of the immune response creates a continuum of the phenotypic severity in KD from mild organ involvement such as gastrointestinal symptoms (e.g., diarrhea, hydrops of the gallbladder) or arthritis, to severe life-threatening complications such as MAS and cardiogenic shock.