Table 1.

PICOS (Population, Intervention, Comparison, Outcomes and Settings) criteria for the inclusion of studies evaluating the effects of vitamin K supplementation on vascular properties.

Parameter	Inclusion Criteria
Population	Adult
Intervention	Controlled Vitamin K (K1 or K2) intake
Comparison	Non-exposed control group
Outcome	Any measurement of vascular calcification, vascular stiffness, vascular flow limitations (e.g., intimal media thickness, pulse wave velocity)
Setting	Randomized controlled trials