Figure 6.

The therapeutic effect of bvPLA2 treatment on the atherosclerotic lesions of Treg-depleted mice. Atherosclerotic lesions were confirmed in the aorta of Treg-depleted mice. (A) The aorta was measured and quantified with Oil red O staining and an “en face” method. (B) Lipid accumulation of the aortic valve, (C) fibrosis, and (D) foam cell formation were measured and quantified in heart sections (magnification ×50). The data are displayed as the means ± SEM (n = 5). The statistical analyses were conducted with Student’s unpaired t test.