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. 2020 Sep 23;12(10):1061. doi: 10.3390/v12101061

Figure 1.

Figure 1

(A) Genotyping result of the maximum likelihood phylogenetic tree of CV-A8 strains constructed based on 34 complete VP1 sequences; the coxsackievirus A3 (CV-A3) prototype strain (AY421761) was used as an outgroup, support was estimated with 1000 bootstrap replicates and the bootstrap cut-off threshold was set to 0.50. The genotypes are differentiated by distinct colours, which are indicated on the left, and the names of the sequences are noted on the right. The Chinese isolates from this study are marked in red, and the Chinese isolates from GenBank are marked in purple. (B) Unrooted maximum likelihood phylogenetic tree of 171 global CV-A8 partial VP1 sequences. Information on the strains detected within each genotype is indicated on the left of the tree. (C) The geographical distribution of CV-A8 genotypes in China. The provinces are indicated by the colour(s) of the circulating genotype(s), the name of each province is located on the map, the provinces that provided the complete VP1 sequence(s) from this study are marked in red and those from GenBank in purple, and the geographic map of China was taken from Highcharts (grant number: 0321912045738052).