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. 2020 Sep 23;9(10):2154. doi: 10.3390/cells9102154

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Figure A5 — Effect of SP treatment on murine spinal cord (A) CD3+ cell infiltration, (B) Mac3+ cell infiltration and (C) demyelination. Spinal cords were extracted from control or SP 30 mg/kg/day-treated EAE-diseased mice (acute phase). Three segments of each spinal cord (cervical, thoracic and lumbar) were evaluated. For each segment, four different regions of interest were analyzed except for demyelination where the complete white matter was analyzed. Control (n = 9), SP 30 mg/kg/day (n = 9) and 3 days of treatment. (A–B) immunohistochemistry and (C) luxol fast blue staining. Each dot represents a measurement. Abbreviations: SC: spinal cord, SEM: standard error of the mean, SP: SP600125 and WM: White matter. Statistic: Mann–Whitney test, #### < 0.0001.