Figure 10.

A schematic model to explain the effects of syndecan-1 overexpression. The central event is the accumulation of intact syndecan-1 molecules on the cell surface. This is achieved directly in cells transfected with the full-length construct and indirectly in cells transfected with the truncated syndecan-1 construct. The downstream effect is reduced Ets-1- and AP-1-mediated promoter activation with subsequent inhibition of cell proliferation and differentiation. RE, response element and GAG, glycosaminoglycan.