Figure 1.

(A) Characterization by transmission electron microscopy. (B) miR-146a cumulative release curves from the nanoparticles. The fluorescence intensities of each sample collected at each time point were measured, and the fluorescence from the blank control was subtracted. The cumulative release curve was calculated based on the obtained concentration. (C) The formulation at room temperature (a, gel/NPs/miR-146a) and at 34 °C (b, gel/miR-146a; c, gel/NPs/miR-146a). The data are expressed as the mean ± SD, n = 4.