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. 2020 Oct 28;33(3):151–157. [Article in Spanish] doi: 10.1016/j.arteri.2020.10.001

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© 2020 Sociedad Española de Arteriosclerosis. Published by Elsevier España, S.L.U. All rights reserved.

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Figura 2 — Mecanismo de infección celular del SARS-CoV-2. El SARS-CoV-2 expresa en su envoltura una proteína denominada proteína S que se une con alta afinidad al dominio extracelular de la enzima conversora de angiotensina 2 (ECA2) provocando la fusión de la membrana y la internalización del virus por endocitosis. Esto resulta en una pérdida de la ECA2 en la superficie de la célula y además la entrada del virus permite su replicación.