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. 2020 Oct 9;16(10):e1008942. doi: 10.1371/journal.ppat.1008942

Fig 3. X-ray crystal structure of the hMPV B2 F + MPV458 Fab complex.

Fig 3

(A) The asymmetric unit of the complex is displayed. Monomeric hMPV B2 F co-crystallized with one Fab of MPV458. (B) Overlay of the hMPV B2 F + MPV458 Fab complex with the previously determined X-ray crystal structure of hMPV A1 F in the pre-fusion conformation (MPV 115-BV, PDB: 5WB0). The hMPV F protein from each structure were overlaid in PyMol. MPV458 clashes with the trimeric structure. (C) Hydrogen bonding events observed between hMPV B2 F and the MPV458 Fab heavy chain. (D) Hydrogen bonding events observed between hMPV B2 F and the MPV458 light chain. The MPV458 light chain also interacts with an extended glycan patch linked from Asn57. CDR is complementarity determining region, FR is framework region. MPV458 numbering is in IMGT format.