Table 1.
Summary of all miRNAs and mRNA interaction and their roles in the EMT process associated with diffuse-type gastric cancer.
| miRNA | mRNA | Function | Ref. |
|---|---|---|---|
| Upregulation miRNAs | |||
| miR-9 | E-cadherin | Upregulation promotes EMT through the direct binding of E-cadherin | [64] |
| miR-199a | E-cadherin | Upregulation promotes EMT through the direct binding of E-cadherin | [66] |
| miR-217 | E-cadherin | Upregulation promotes EMT through the direct binding of E-cadherin | [67] |
| miR-544a | E-cadherin | Upregulation promotes EMT through the direct binding of E-cadherin | [68] |
| Downregulation miRNAs | |||
| miR-141 | ZEB1/2 | Downregulation promotes EMT by increasing ZEB1 and ZEB 2 | [69] |
| miR-200c | ZEB1/2 | Downregulation promotes EMT by increasing ZEB1 and ZEB 2 | [69] |
| miR-200c | ZEB1/2 | Downregulation promotes EMT by increasing ZEB1 and ZEB 2 | [70] |
| miR-205-3p | ZEB1/2 | Downregulation promotes EMT by increasing ZEB1 and ZEB2 | [71] |
| miR-574-3p | ZEB1 | Downregulation promotes EMT by increasingZEB1 | [72] |
| miR-145 | ZEB2 | Downregulation promotes EMT by increasing ZEB2 | [73] |
| miR-200b | ZEB2 | Downregulation promotes EMT by increasing ZEB2 | [74] |
| miR-338-3p | ZEB2 | Downregulation promotes EMT by increasing ZEB2 | [75] |
| miR-506 | ZEB2 | Downregulation promotes EMT by increasing ZEB2 | [76] |
| miR-22 | Snail | Downregulation promotes EMT by increasing Snail | [77] |
| miR-153 | Snail | Downregulation promotes EMT by increasing Snail | [78] |
| miR-195 | Snail | Downregulation promotes EMT by increasing Snail | [79] |
| miR-204 | Snail | Downregulation promotes EMT by increasing Snail | [80] |
| miR-491 | Snail | Downregulation promotes EMT by increasing Snail | [81] |
| miR-33a | Slug | Downregulation promotes EMT by increasing Slug | [82] |
| miR-124 | Slug | Downregulation promotes EMT by increasing Slug | [83] |
| miR-203 | Slug | Downregulation promotes EMT by increasing Slug | [84] |
| miR-506 | Slug | Downregulation promotes EMT by increasing Slug | [85] |
| miR-15a-3p | Twist | Downregulation promotes EMT by increasing Twist | [86] |
| miR-16-1-3p | Twist | Downregulation promotes EMT by increasing Twist | [86] |
| miR-186 | Twist | Downregulation promotes EMT by increasing Twist | [87] |
| miR-381 | Twist | Downregulation promotes EMT by increasing Twist | [88] |
| miR-495 | Twist | Downregulation promotes EMT by increasing Twist | [89] |