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. 2020 Sep 24;12(10):913. doi: 10.3390/pharmaceutics12100913

Figure 1.

Figure 1

Representative images of mCherry (A–E, red) and GFP (F–J, green) reporter expression after sub-retinal injections of ssAAV-Anc80 solutions, as seen in the whole mount and retinal sections. (A,C) Retinas treated with ssAAV-Anc80-anti-miR-6937-5p. (B,E) Retinas treated with ssAAV-Anc80-scramble-inhibitor. (F,H) Retinas treated with ssAAV-Anc80-pre-miR-142a-5p. (G,J) Retinas treated with ssAAV-Anc80-scramble-precursor. (D,I) Expression of AAV-Anc80 is restricted to photoreceptor cells, as can be observed in high magnification of retinal sections with nuclei stained with DAPI (blue). Abbreviations: INL: inner nuclear layer; ONL: outer nuclear layer; AAV: adeno-associated virus. Scale bars: 400 μm, except in (D,J): 50 μm.