Table 1.

Antiproliferative properties of the synthesised compounds

Comp.	Conc. (µM)	Inhibition (%) ± SEM [calculated IC50]a
		A2780	MDA- MB-231	MCF-7
11a	10	44.87 ± 0.09	47.49 ± 1.21	29.06 ± 1.42
	30	52.00 ± 0.80	38.18 ± 2.78	36.49 ± 1.22
		[21.51]
11b	10	30.18 ± 2.35	24.39 ± 2.20	–b –
	30	33.94 ± 2.70	23.92 ± 1.07
12a	10	93.16 ± 0.47	52.94 ± 1.32	41.98 ± 0.97
	30	95.43 ± 0.42	53.81 ± 2.43	52.50 ± 0.94
		[0.55]	[8.80]	[12.69]
12b	10	46.93 ± 1.75	–	23.46 ± 1.03
	30	54.72 ± 0.70	–	29.19 ± 2.94
		[18.34]
13a	10	29.53 ± 1.86	–	–
	30	90.85 ± 0.40	35.95 ± 3.17	43.54 ± 2.63
		[13.52]
13b	10	95.61 ± 0.59	57.03 ± 2.58	73.99 ± 1.88
	30	99.73 ± 0.21	98.93 ± 0.20	95.52 ± 0.23
		[2.95]	[9.51]	[6.59]
14a	10	95.97 ± 1.28	81.95 ± 2.49	66.93 ± 1.46
	30	98.06 ± 0.89	98.52 ± 0.10	92.52 ± 1.08
		[4.87]	[7.13]	[8.38]
14b	10	85.52 ± 0.64	46.57 ± 1.21	77.87 ± 0.66
	30	95.82 ± 0.12	71.28 ± 1.23	90.69 ± 0.18
		[5.07]	[13.64]	[7.16]
15a	10	79.93 ± 1.08	25.67 ± 1.76	42.44 ± 2.94
	30	99.50 ± 0.03	96.87 ± 0.28	91.04 ± 1.49
		[5.91]	[13.15]	[11.39]
15b	10	46.25 ± 1.27	–	30.14 ± 1.53
	30	92.05 ± 0.86	34.79 ± 2.20	77.45 ± 1.56
		[9.96]
Cisplatin		83.57 ± 1.21	67.51 ± 1.01	53.03 ± 2.29
		95.02 ± 0.28	87.75 ± 1.10	86.90 ± 1.24
		[1.30]	[3.70]	[5.78]

^aMean value from two independent measurements with five parallel wells; standard deviation <20%.

^bInhibition values <20% are not presented.