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Effects of nutrient sensor signalling on the cellular mechanisms that underlie cardioprotection. Cellular mechanisms are shown in blue, and cardiac responses are shown in red. Akt, protein kinase B; mTORC1, mammalian target of rapamycin complex 1; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator-1alpha; SIRT1, sirtuin-1.
