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. 2020 May 27;41(39):3856–3861. doi: 10.1093/eurheartj/ehaa360

Figure 2.

Figure 2

Mutual enhancement and antagonism of nutrient sensor signalling in the regulation of autophagic flux in cardiomyocytes. Nutrient deprivation sensors that promote autophagic flux are shown in blue, whereas the nutrient surplus sensors that suppress autophagy are shown in red. Akt, protein kinase B; AMPK, adenosine monophosphate-activated protein kinase; mTORC1, mammalian target of rapamycin complex 1; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator-1 alpha; SIRT1, sirtuin-1.