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Pathways that mediate and influence the interplay of lifespan extension, cardiac ageing, and the development of cardiomyopathy. Akt, protein kinase B; AMPK, adenosine monophosphate-activated protein kinase; mTORC1, mammalian target of rapamycin complex 1; PGC-1α, peroxisome proliferator-activated receptor-gamma coactivator-1 alpha; SIRT1, sirtuin-1.
