Fig. 4.

α-Axl antibody treatment significantly reduces the number of Iba1⁺ microglia in the spinal cord during chronic EAE. A Representative lumbar spinal cord sections from PBS- (n = 3), IgG isotype control- (n = 3), or α-Axl-activating antibody-treated (n = 4) mice during chronic EAE. (a–c) H&E, (d–f) Iba1⁺ microglia/macrophages, and (g–i) SMI32⁺ axonal swellings (scale bar = 100 μm). Quantification of B Iba1, C CD3, and D SMI32 axonal swellings. *p ≤ 0.05, **p ≤ 0.01, and ***p ≤ 0.001, Mann-Whitney U test