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GRADE recommendation.
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Certainty | Importance |
|---|---|---|---|---|---|---|---|---|
| DFS | ||||||||
| 5 | randomized trials | not serious | seriousa | not serious | not serious | none | ⊕⊕⊕◯ MODERATE | Important |
| OS | ||||||||
| 5 | randomized trials | not serious | not serious | not serious | seriousb | none | ⊕⊕⊕◯. MODERATE | Important |
CI: Confidence interval
Explanations
a. Only one trial was able to show non-inferiority
b. Wide confidence intervals in OS results
