Table 2.
Multivariable analysis of factors influencing the decision to perform completing axillary lymph node dissection in patients with T3–T4 cN0 early breast cancer and one or two tumor-affected sentinel lymph nodes since publication of the ACOSOG Z0011 results
| Variable | Odds ratio (95% CI) | p value |
|---|---|---|
| Type of hospital | ||
| General, non-academic hospital | Reference | |
| Academic teaching hospital | 1.12 (0.75–1.67) | 0.576 |
| University hospital | 1.12 (0.50–2.67) | 0.783 |
| Annual hospital caseload | ||
| < 150 | Reference | |
| 150–249 | 1.53 (0.97–2.43) | 0.07 |
| ≥ 250 | 2.16 (1.30–3.62) | 0.003 |
| Age (years) | 0.96 (0.94–0.98) | < 0.001 |
| Tumor stage | ||
| 3 | Reference | |
| 4 | 0.99 (0.63–1.56) | 0.97 |
| Type of metastasis | ||
| Macro | Reference | |
| Micro | 0.08 (0.04–0.17) | < 0.001 |
| Sentinel removed | 0.70 (0.62–0.80) | < 0.001 |
| Sentinel affected | 2.08 (1.31–3.37) | 0.002 |
| Surgical procedure | ||
| BCT | Reference | |
| BCT with re-excision | 0.92 (0.39–2.25) | 0.84 |
| Mastectomy | 1.58 (0.94–2.64) | 0.08 |
| Mastectomy with re-excision | 1.78 (0.25–36.9) | 0.62 |
| Grading | ||
| G1 (low) | Reference | |
| G2 (intermediate) | 1.05 (0.47–2.22) | 0.90 |
| G3 (high) | 1.21 (0.50–2.84) | 0.67 |
| Lymphovascular invasion | ||
| No | Reference | |
| Yes | 1.28 (0.86–1.91) | 0.23 |
| Histological subtype | ||
| Ductal | Reference | |
| Lobular | 0.61 (0.71–1.79) | 0.61 |
| Other | 0.33 (0.59–5.94) | 0.33 |
| Hormone receptor status | ||
| Negative | Reference | |
| Positive | 0.89 (0.37–1.98) | 0.78 |
| HER2 receptor status | ||
| Negative | Reference | |
| Positive | 1.12 (0.59–2.18) | 0.74 |
| ECOG performance status | ||
| 0 | Reference | |
| 1 | 0.58 (0.36–0.93) | 0.02 |
| 2 | 1.12 (0.48–2.69) | 0.81 |
CI confidence interval, BCT breast-conserving therapy, ECOG Eastern Cooperative Oncology Group