Fig. 3.

Habitat definition and volume rendering. After manual definition of tumor-bearing area (a, green) and surrounding normal-appearing tissue (a, orange) in representative image series, a semi-automatic grow from seeds algorithm was applied (b) obtaining a three-dimensional habitat of the whole volume of interest (VOI) with exemplary volume rendering from four points of view being shown (c: (a) anterior; (p) posterior; (l) left; (r) right). For each specimen, normal-appearing peripheral zone was delineated by manual VOI placement (d, blue)