Table 1.
Clinical and epidemiological characteristics of included patients
| Variable | Study cohort |
|---|---|
| Patients | 73 (100) |
| Radical prostatectomy (RPX) | 33 (45) |
| MRI-guided biopsy | 30 (41) |
| MRI-/US-fusion biopsy | 10 (14) |
| Median age at definite diagnosis (years)* | 66 (35–83) |
| Median time (months)*, MRI to tissue (biopsy, RPX) | 0 (0–7) |
| Prior biopsy with post-biopsy changes in T1w*** | 30 (41.1) |
| Mean PSA (ng/mL)** | 12.14 (13.9; 15.8; 8.4) [NA: 16] |
| Localization (index lesion) | |
| PZ | 66 |
| PZ/AFS | 7 |
| Median number of intra-prostatic lesions* | 2 (1–3) |
| PI-RADS, index lesion*** | |
| 3 | 8 (11) |
| 4 | 26 (36) |
| 5 | 39 (53) |
| Gleason score, index lesion*** | |
| 3 + 3 | 15 (21) |
| 3 + 4 | 23 (32) |
| 4 + 3 | 15 (21) |
| 4 + 4 | 5 (7) |
| 4 + 5 | 11 (15) |
| 5 + 3 | 1 (1) |
| 5 + 4 | 1 (1) |
| 5 + 5 | 2 (3) |
| Gleason Grade Group, index lesion*** | |
| 1 | 15 (21) |
| 2 | 23 (32) |
| 3 | 15 (21) |
| 4 | 6 (8) |
| 5 | 14 (19) |
| Available, sufficient quality of sequences *** | |
| T2w | 72 (99) |
| ADC | 73 (100) |
| DCE | 68 (93) |
| pTNM, RPX-cohort*** | 33 (100) |
| pT2a | 2 (6) |
| pT2b | 1 (3) |
| pT2c | 13 (40) |
| pT3a | 12 (36) |
| pT3b | 5 (15) |
| pN0 | 29 (88) |
| pN1 | 2 (6) |
| pNX | 2 (6) |
| pM0 | 31 (94) |
| pM1 | 1 (3) |
| pMX | 1 (3) |
| pR0 | 24 (73) |
| pR1 | 8 (24) |
| pRX | 1 (3) |
If not otherwise depicted, the numbers without parenthesis depict absolute numbers. *Data in round parenthesis are the min/max values (interquartile range); **Data in round parenthesis are standard deviation and ± 95% confidence interval; ***Data in round parenthesis are relative values; Data in square parenthesis are not available values, excluded in the analysis; due to mathematical rounding, the summed relative values may differ slightly from 100. ADC, apparent diffusion coefficient; AFS, anterior fibromuscular stroma; DCE, dynamic contrast enhanced; MRI, magnetic resonance imaging; NA, not available; PI-RADS, Prostate Imaging Reporting and Data System; PSA, prostate-specific antigen; PZ, peripheral zone; RPX, radical prostatectomy; T1w, T1-weighted; T2w, T2-weighted; US, ultrasonography