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. 2020 Oct 30;11:5482. doi: 10.1038/s41467-020-19311-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Histogram of small NUIs (<50 bp) disrupting exons. The 3 bp periodic trend shows that the majority of these events are in-frame, suggesting that that a strong evolutionary constraint is in place to preserve the structural and functional integrities of the proteins. b Density plot comparing the 3 bp periodic trend in exonic (blue) versus non-exonic (yellow) NUIs. c Horizontal barplot showing the pLI scores distributions of genes whose exons are disrupted by in-frame or out-of-frame small NUIs. d As in c but exonic and non-exonic NUIs of all size ranges are compared.