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. 2020 Oct 30;3:635. doi: 10.1038/s42003-020-01360-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Scheme of the granular layer network and circuit wiring of a unit reconstructed in the model. The granule cells are activated by mossy fibers terminating in the glomeruli and are inhibited by Golgi cells. The Golgi cells are excited by mossy fibers, ascending axons and parallel fibers; are coupled by gap junctions and are connected by reciprocal inhibitory synapses. Network activity was elicited by stimulating the glomeruli. The full network reproduces an 800 × 800 × 150 µm³ portion of the granular layer, comprising 384000 granule cells, 914 Golgi cells and 29415 glomeruli. b Scheme of the granular layer wiring between granule cells, Golgi cells and glomeruli. Arrows indicate the flux of signals in and out of the glomerulus. c The model is used to determine the size of the microcircuit units generating responses compatible with SLM-2PM recordings such as those reported in Fig. 1. A C/S response structure emerged by activating more than 10 neighboring glomeruli. In this and the following figures, simulations were carried out by stimulating 50 adjacent glomeruli.