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. 2020 Oct 30;3:635. doi: 10.1038/s42003-020-01360-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–c Cellular firing caused by HFS (the same as in the experimental induction protocol) determines Ca²⁺ influx through synaptic NMDA receptor channels and the consequent increase in intracellular Ca²⁺ concentration. The membrane voltage (average voltage), NMDA current (integral of the current) and Ca²⁺ concentration (peak concentration) vary from cell to cell depending on the local connectivity inside the microcircuit unit, as shown in the 3D activity maps. d The Bear–Lisman rule was used to calculate the neurotransmission changes induced by the Ca²⁺ concentrations reached during HFS. e The mossy fiber release probability changed accordingly (plotted here over the receiving granule cells) to account for LTP or LTD expression.