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. 2020 Oct 30;5:19. doi: 10.1038/s41536-020-00103-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A After NETs and macrophages are cocultured, the elastase in macrophages will increase; B the elastase RNA level of macrophages cocultured with NETs did not change significantly; C proteinase K can reduce elastase in NETs; D after NETs were treated with proteinase K and cocultured with macrophages, the elastase of macrophages did not increase significantly; E after elastase was cocultured with macrophages, the elastase in macrophages was also increased; F alvelestat (elastase inhibitor) decreased the expression of elastase in the NETs-treated macrophages; G NETs activated Smad3 and P65 in macrophages; H, I SIS3 (Smad3 inhibitor) or BAY-11-7082 (P65 inhibitor) mitigated the effects of NETs on the expression of fibronectin in macrophages. All blots or gels derive from the same experiment and that they were processed in parallel. Error bars = SEM; Student’s t test for two groups comparison, two-way ANOVA for three and more groups comparison, number indicated in the figure; ns not significant; *p < 0.05; **p < 0.01; ***p < 0.001.