Table 3.

C-statistics and NRI for ASCVD and CVM in validation datasets.

		ASCVD		CVM
		eGFR patch	CKD patch	eGFR patch	CKD patch
N		4,489,273	1,153,790	875,693	419,732
Base C-statistic (IQI)		0.755 (0.698, 0.772)	0.687 (0.665, 0.726)	0.711 (0.621, 0.790)	0.680 (0.569, 0.732)
ΔC-statistic (95% CI)		0.002 (0.001, 0.002)	0.010 (0.007, 0.013)	0.008 (0.005, 0.011)	0.027 (0.018, 0.036)
Categorical NRI (95% CI) cut point at 7.5%, 20% for ASCVD, 5% and 10% for CVM	Overall	0.039 (0.031, 0.047)	0.056 (0.044, 0.067)	0.035 (0.013, 0.056)	0.080 (0.032, 0.127)
	Event	0.059 (0.050, 0.068)	0.084 (0.066, 0.102)	0.070 (0.046, 0.094)	0.065 (0.007, 0.123)
	Non-event	−0.020 (−0.023, −0.017)	−0.016 (−0.027, −0.005)	−0.028 (−0.033, −0.023)	0.037 (−0.007, 0.080)

ASCVD: atherosclerotic cardiovascular disease; CKD: chronic kidney disease; CVM: cardiovascular mortality; eGFR: estimated glomerular filtration rate; NRI: net reclassification improvement.