Table 2.
Linear regression of PASP, entire cohort.
Variables | β-estimate (mmHg) [95% CI]* |
p value |
---|---|---|
HIV/HCV status | ||
Uninfected | Ref | – |
HIV mono-infected | 0.002 [− 0.93, 0.93] | 0.9963 |
HCV mono-infected | 0.45 [− 0.66, 1.57] | 0.4259 |
Co-infected | 1.10 [0.01, 2.20] | 0.0484 |
Age, 10 years | 0.21 [− 0.22, 0.63] | 0.3453 |
Race | ||
White | Ref | – |
African American | 2.02 [ 1.20, 2.85] | < .0001 |
Hispanic | − 3.31 [− 4.56, − 2.06] | < .0001 |
Other | 0.16 [− 2.17, 2.49] | 0.8953 |
Male Sex | 7.40 [5.31, 9.50] | < .0001 |
BMI | 0.04 [− 0.02, 0.10] | 0.2436 |
Heart failure status | ||
HF Preserved EF | 7.83 [6.18, 9.48] | < .0001 |
HF with EF between 40 & 50 | 6.46 [4.00, 8.92] | < .0001 |
HF Reduced EF | 5.78 [4.37, 7.18] | < .0001 |
No EF | 7.94 [6.90, 8.98] | < .0001 |
No HF | Ref | – |
History of CHD | 1.02 [0.24, 1.80] | 0.0102 |
Hypertension | ||
No Hypertension | Ref | – |
Controlled HTN | 0.31 [− 1.27, 1.88] | 0.7003 |
Uncontrolled HTN | 1.65 [− 0.02, 3.31] | 0.0523 |
COPD | 1.96 [1.19, 2.72] | < .0001 |
Stroke History | − 1.19 [− 2.55, 0.16] | 0.0844 |
Diabetes Mellitus | 0.89 [0.13, 1.66] | 0.0214 |
Dyslipidemia | − 0.44 [− 1.18, 0.30] | 0.2480 |
Smoking status | ||
Current | 0.46 [− 0.50, 1.43] | 0.3438 |
Former | 0.91 [− 0.19, 2.02] | 0.1049 |
Never | Ref | – |
Alcohol Use | 0.21 [− 0.67, 1.09] | 0.6346 |
Cocaine Use | − 1.53 [− 2.55, − 0.50] | 0.0034 |
eGFR | − 0.03 [− 0.04, − 0.01] | < .0001 |
FIB-4 | 0.31 [0.17, 0.45] | < .0001 |
Hemoglobin | − 0.75 [− 0.94, − 0.56] | < .0001 |
PASP pulmonary arter systolic pressure, HCV hepatitis C virus, CI confidence interval, BMI body mass index, HF heart failure, EF ejection fraction, CHD coronary heart disease, HTN hypertension, COPD chronic obstructive pulmonary disease, eGFR estimated glomerular filtration rate; FIB-4 fibrosis 4 score.
*All estimates are from a multiple linear regression adjusted for all listed variables. Estimates per one unit increase unless otherwise specified.