Skip to main content
. 2020 Oct 30;11(10):937. doi: 10.1038/s41419-020-03130-4

Fig. 3. P53 and p21 are involved in the OIS induced by SET8 in GC.

Fig. 3

A SET8 positively regulated p53/p21 mRNA and protein levels (left). Senescence markers activated by SET8 were determined by western blot (right). B Senescence-associated secretory factors were detected by qRT-PCR. C Assays of SA-β-Gal staining. The bar graph at the bottom shows the proportion of SA-β-Gal-positive cells. SET8 regulated senescence was indicated by the expression of senescence markers. *P < 0.05. NC, negative control; si, siRNA.