Table 2.
Clinicopathologic findings of gastric cancer patients.
| Family history of gastric cancer | p value | ||||
|---|---|---|---|---|---|
| Absent (n = 251) | Present (n = 65) | ||||
| No. | % | No. | % | ||
| Tumor location | 0.17 | ||||
| Upper third | 29 | 11.6 | 8 | 12.3 | |
| Middle third | 79 | 31.5 | 13 | 20 | |
| Lower third | 139 | 55.4 | 41 | 63.1 | |
| All | 4 | 1.6 | 3 | 4.6 | |
| Tumor size (cm) | 0.78 | ||||
| <1.0 | 46 | 18.3 | 11 | 16.9 | |
| 1.0-1.9 | 73 | 29.1 | 19 | 29.2 | |
| 2.0-2.9 | 41 | 16.3 | 14 | 21.5 | |
| ≥3.0 | 91 | 36.3 | 21 | 32.3 | |
| Mean + SD | 2.8 ± 2.3 | 2.8 ± 2.5 | 0.991 | ||
| Differentiation | 0.197 | ||||
| Differentiated | 132 | 52.6 | 40 | 61.5 | |
| Undifferentiated | 119 | 47.4 | 25 | 38.5 | |
| Laruen classification | 0.491 | ||||
| Intestinal | 133 | 57.1 | 39 | 61.9 | |
| Diffuse or mixed | 100 | 42.9 | 24 | 38.1 | |
| Depth of invasion | 0.756 | ||||
| pT1 | 193 | 76.9 | 49 | 75.4 | |
| pT2 | 32 | 12.7 | 11 | 16.9 | |
| pT3 | 13 | 5.2 | 3 | 4.6 | |
| pT4 | 13 | 5.2 | 2 | 3.1 | |
| Lymph node metastasis | 0.235 | ||||
| pN0 | 199 | 79.3 | 56 | 86.2 | |
| pN1 | 26 | 10.4 | 6 | 9.2 | |
| pN2 | 15 | 6 | 0 | 0 | |
| pN3 | 11 | 4.4 | 3 | 4.6 | |
| Multiplicity of tumor | 0.653 | ||||
| Solitary | 239 | 95.2 | 61 | 93.8 | |
| Multiple | 12 | 4.8 | 4 | 6.2 | |
| Stage | 0.698 | ||||
| I | 204 | 81.3 | 56 | 86.2 | |
| II | 28 | 11.2 | 4 | 6.2 | |
| III | 8 | 3.2 | 2 | 3.1 | |
| IV | 11 | 4.4 | 3 | 4.6 | |
| Preexisting adenoma | 0.035 | ||||
| Yes | 15 | 6.3 | 9 | 14.5 | |
| No | 222 | 93.7 | 53 | 85.5 | |
| Microsatellite instability | 0.006 | ||||
| Stable | 86 | 86.8 | 21 | 56.8 | |
| Unstable, low (MSI-L) | 6 | 6.1 | 7 | 18.9 | |
| Unstable, high (MSI-H) | 7 | 7.1 | 9 | 24.3 | |
| Curative treatment method | 0.538 | ||||
| ESD | 78 | 32.6 | 18 | 28.6 | |
| Surgery (STG+TG) | 161 | 67.4 | 45 | 71.4 | |
| H. pylori infection status | 0.188 | ||||
| Yes | 138 | 61.3 | 43 | 70.5 | |
| No | 87 | 38.7 | 18 | 29.5 | |
| Atrophic gastritis | 0.354 | ||||
| Yes | 231 | 92 | 62 | 95.4 | |
| No | 20 | 8 | 3 | 4.6 | |
| Intestinal metaplasia | 0.113 | ||||
| Yes | 137 | 53.8 | 44 | 67.7 | |
| No | 114 | 45.4 | 21 | 32.3 | |
ESD: endoscopic submucosal dissection; H. pylori: Helicobacter pylori; SD: standard deviation; STG: subtotal gastrectomy; TG: total gastrectomy. Microsatellite instability was evaluated in 136 of the patients (43% of total study population) who underwent ESD or surgery.