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The 2-cell block: A novel protein thiol-dependent mechanism. The scheme depicts mitochondria-derived hydrogen peroxide oxidizing the catalytic (Cys373) thiol of the tyrosine protein phosphatase cdc25c to a sulfenic acid (SOH). Thiol oxidation renders cdc25c unable to dephosphorylate target substrates. The resultant perturbation in zygotic phosphorylation tone could cause cell cycle arrest.
