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. 2020 Oct 8;10(10):1426. doi: 10.3390/biom10101426

Figure 1.

Figure 1

Effect of gypenoside LXXV (Gyp LXXV) on cell viability and fibrosis in hepatic stellate cells (LX-2). Cell viability of Gyp LXXV or Rg3 on LX-2 cells (a). Cells were treated with increasing concentrations of Gyp LXXV or Rg3 (0.01–10 μg/mL) for 24 h. Gyp LXXV-mediated inhibition of fibrosis markers, α-smooth muscle actin (α-SMA) (b) and collagen1 (c), via transforming growth factors-β (TGF-β) (4 ng/mL)-induced LX-2 activation (n = 3 for each group). * p < 0.05, ** p < 0.01 vs. TGF-β. MCC950 (MCC; 1 μM) or pioglitazone (Pio; 10 μM) was used as positive controls.