Skip to main content
. 2020 Oct 1;9(10):320. doi: 10.3390/biology9100320

Figure 5.

Figure 5

Effects of individual and combined treatment of JNK-IN-8 on cell viability and cellular survival of wt and PTX-res MCF-7 cells. (A) The cell viability of wt and PTX-res MCF-7 cells was determined by MTT cell viability assay following treatment of individual PTX or JNK inhibitor and combination of both agents. (B) The expression profiles of p38 MAPK, p-p38 MAPK, SAPK/JNK, p-SAPK/JNK, E-cadherin, Vimentin, and MDR/ABCB1 gene were determined by immunoblotting in wt and PTX-res MCF-7 breast cancer cells following 24 h PTX and JNK-IN-8 treatment. β-actin was used as a loading control. Densitometry analysis was shown at Figure S3 from different batches of PTX-resistant MCF-7 cells. * p < 0.05; ** p < 0.001.