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. 2020 Oct 7;11(10):1174. doi: 10.3390/genes11101174

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Transcript levels of hormone receptors and downstream substrates in prostate-cancer cell lines and in human prostate-cancer tissue. Transcript levels of indicated genes measured using real-time PCR. (A) AR, (B) KLK3, (C) FOLH1, (D) INSRA, (E) INSRB, (F) INSRA/INSRB ratio, (G) IRS1, (H) IRS2, (I) IRS1/IRS2 ratio. PCa: prostate cancer, HPEC: parental primary prostate cells, CWR-R1ca: xenograft PCa cells, DU145: brain metastasis PCa cells, LNCaP: lymph-node metastasis PCa cells, NCI-H660: lymph-node metastasis PCa cells, MDA-PCa-2b: bone metastasis PCa cells, PC3: bone metastasis PCa cells, nd: not detected. For human PCa samples, data shown as pooled samples: mean ± standard deviation (n = 11).