Table 3.
RNA sequencing data from https://www.cbioportal.org/ [25].
| Cell Line | DU145 | LNCaP | NCI-H660 | MDA-PCa-2b | PC3 |
|---|---|---|---|---|---|
| Gene ID | |||||
| AR | 0.0934 | 52.35 | 0.0104 | 24.77 | 0.0098 |
| KLK3 | 0.0152 | 3066.78 | 0 | 3292.29 | 0 |
| FOLH1 | 0.0447 | 473.17 | 0.0119 | 308.79 | 0.1089 |
| INSR * | 1.27 | 5.68 | 6.41 | 5.39 | 1.87 |
| IRS1 | 3.59 | 2.50 | 2.15 | 5.40 | 7.05 |
| IRS2 | 3.44 | 0.8080 | 2.80 | 6.19 | 0.7902 |
| ESR1 | 0.0184 | 0.0015 | 0.9132 | 0.0016 | 0.2013 |
| ESR2 | 0.1613 | 0.0867 | 0.5153 | 0.0632 | 0.2337 |
| ESRRA | 11.19 | 27.04 | 12.65 | 29.41 | 19.22 |
| IGF1R | 5.41 | 9.46 | 6.21 | 22.71 | 1.58 |
| FGFR1 | 13.30 | 2.68 | 0.3394 | 3.32 | 5.23 |
| CYP27A1 | 3.42 | 0.0650 | 0.1743 | 0.0264 | 5.67 |
| CYP7B1 | 0.0550 | 0 | 0.3231 | 0.0092 | 0.7905 |
| CYP46A1 | 0.0446 | 0.2518 | 0.1962 | 0.1349 | 0.1359 |
| CH25H | 0.0455 | 0.0151 | 0.0282 | 0 | 0.0157 |
| MKI67 | 58.09 | 16.15 | 38.52 | 26.22 | 24.39 |
| CCND1 | 129.71 | 110.32 | 0.6017 | 98.12 | 232.60 |
| TP53 | 32.21 | 39.17 | 5.85 | 17.03 | 1.01 |
| HIF1A | 111.95 | 40.72 | 54.63 | 123.32 | 83.55 |
| RELA | 27.04 | 19.18 | 20.18 | 19.53 | 16.76 |
| BIRC5 | 6.84 | 2.61 | 4.12 | 2.57 | 6.09 |
| NOS2 | 0.5080 | 0 | 0.0462 | 0 | 0.0081 |
| SEPP1 | 0.6737 | 27.18 | 34.10 | 44.55 | 1.32 |
| CDKN1A | 18.73 | 92.39 | 52.25 | 40.94 | 4.49 |
| CDKN1B | 17.72 | 28.15 | 40.70 | 32.49 | 8.18 |
| GLUT1 | 68.77 | 19.17 | 10.53 | 25.15 | 63.88 |
| GLUT12 | 0.5633 | 26.02 | 0.9042 | 6.98 | 0.6577 |
Numbers denote median values.* Applied method did not distinguish between INSRA and INSRB isoforms, which were, however, differentiated by our qPCR analysis.