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. 2020 Oct 5;12(10):2865. doi: 10.3390/cancers12102865

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CD200 in FL tolerogenic niche. (A) CD200 mRNA expression analyzed by Affymetrix probeset intensity in stromal cells from non-tumoral (n_STRO) or FL (FL_STRO) contexts, B lymphocytes from tonsil (TONS_BGC) or FL lymph node (FL_B) and Tfh lymphocytes from tonsil (TONS_Tfh) or FL lymph node (FL Tfh). ns: non-significant, ** p < 0.01; (B) Flow cytometry expression of CD200R on dendritic cells (DC) from FL lymph nodes (black histogram) compared to isotype control (white histogram). DC were phenotypically defined as CD3^negCD19^negCD335^negCD11c^posHLA-DR^posCD14^neg viable cells. One representative graph out of three experiments is shown; (C) INDO mRNA expression by qRT-PCR of immature DC with or without CD200R in vitro stimulation (20 µg/mL) for 2 days (n = 6), * p < 0.05; (D) IDO activity evaluated by kynurenine/tryptophan ratio on DC cultured or not with MSC and stimulated or not with anti-CD200R antibody (20 µg/mL) for 2 days.