Table 1.

Licensed disease-modifying drugs in multiple sclerosis [19,20,21,22,23,24,25,26].

Class	Drugs	Indications
Immunomodulators	Interferon beta (IFN-β)	CIS Active RRMS
	Methylprednisolone	Acute flare-ups RRMS Relapse prevention
	Glatiramer acetate (GA)	CIS Active RRMS
	Dimethyl fumarate	Active RRMS
	Diroximel fumarate	CIS RRMS Active SPMS
	Fingolimod	Active RRMS High-active RRMS
	Teriflunomide	Active RRMS
	Siponimod	CIS RRMS SPMS
Immunosuppressors	Alemtuzumab	Active RRMS
	Natalizumab	High-active RRMS
	Ocrelizumab	Active RRMS High-active RRMS PPMS
	Ofatumumab	CIS RRMS Active SPMS
Cytotoxic Agents	Cladribine	High-active RRMS
	Mitoxantrone	High-active RRMS