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. 2020 Oct 7;13(10):295. doi: 10.3390/ph13100295

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of the combination of lutein/zeaxanthin, curcumin and vit D (LCD) on serum malondialdehyde (MDA), corneal MDA, corneal superoxide dismutase (SOD), and corneal glutathione peroxidase (GSH-Px), in benzalkonium chloride (BAC)-induced dry eye syndrome in rats (n = 7 per group). Control: No treatment; Dry Eye: BAC-induced dry eye syndrome; LCD I; Dry Eye + LCD I: BAC-induced dry eye syndrome plus LCD I (100 mg/kg body weight); Dry Eye + LCD II: BAC-induced dry eye syndrome plus LCD II (200 mg/kg body weight). Data are presented as a bar with means and standard deviations. (ANOVA and Tukey′s post-hoc test. Statistical significance between groups is shown by: * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001 compared as control group; ^## p < 0.01; ^### p < 0.001; ^#### p < 0.0001 compared as Dry Eye group; ^$ p < 0.05; ^$$ p < 0.01 compared as Dry Eye + LCD I group).

Effect of the combination of lutein/zeaxanthin, curcumin and vit D (LCD) on serum malondialdehyde (MDA), corneal MDA, corneal superoxide dismutase (SOD), and corneal glutathione peroxidase (GSH-Px), in benzalkonium chloride (BAC)-induced dry eye syndrome in rats (n = 7 per group). Control: No treatment; Dry Eye: BAC-induced dry eye syndrome; LCD I; Dry Eye + LCD I: BAC-induced dry eye syndrome plus LCD I (100 mg/kg body weight); Dry Eye + LCD II: BAC-induced dry eye syndrome plus LCD II (200 mg/kg body weight). Data are presented as a bar with means and standard deviations. (ANOVA and Tukey′s post-hoc test. Statistical significance between groups is shown by: * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001 compared as control group; ^## p < 0.01; ^### p < 0.001; ^#### p < 0.0001 compared as Dry Eye group; ^$ p < 0.05; ^$$ p < 0.01 compared as Dry Eye + LCD I group).