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. 2020 Oct 7;13(10):295. doi: 10.3390/ph13100295

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of the combination of lutein/zeaxanthin, curcumin and vit D (LCD) on histopathological changes in benzalkonium chloride (BAC)-induced dry eye syndrome in rats. Control: No treatment; Dry Eye: BAC-induced dry eye syndrome; LCD I; Dry Eye + LCD I: BAC-induced dry eye syndrome plus LCD I (100 mg/kg body weight); Dry Eye + LCD II: BAC-induced dry eye syndrome plus LCD II (200 mg/kg body weight). Control: A histological appearance of a normal cornea. Dry Eye: The increased thickness of the corneal epithelium, inflammatory cell infiltration, and edema under the epithelium. Dry Eye + LCD I: Mild epithelial thickness, mild edema under the epithelium, and disappearance in infiltration. Dry Eye + LCD II: Normal appearance in epithelium thickness and very mild edema.