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. 2020 Sep 29;10(10):1945. doi: 10.3390/nano10101945

Figure 4.

Figure 4

Extracellular matrix-penetrating polymeric micelles for liver fibrosis therapy. (A) Schematic illustration of the preparation of four different polymeric micelles. (B) Schematic illustration of the proposed destiny of the four different polymeric micelles in vivo. The CRM/NIL is able to penetrate the collagen barrier and target activated HSCs. Internalization of CRM/NIL allows the release of NIL, which reduces expression of the metallopeptidase inhibitor, TIMP-1, which in turn enhances collagen I degradation, thereby exerting therapeutic action against liver fibrosis. Reproduced with permission from [100]. Copyright Elsevier, 2020.