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. 2020 Sep 29;10(10):1945. doi: 10.3390/nano10101945

Figure 5.

Figure 5

Vitamin A–decorated pH-sensitive and SPIO-loaded nanocomplex T-PBP@miRNA/SPIO (T-miRNA/S) for miRNA targeting delivery in the therapy of liver fibrosis. Expression of liver fibrosis-related genes for alleviating liver fibrosis were synergistically downregulated. The red arrows indicate the reduction of COL1A1, TIMP1, and collagen fiber. Abbreviations: COL1A1, collagen type I alpha 1 protein; TIMP1, tissue inhibitor of metalloproteinase 1; SPIO, superparamagnetic iron oxide. Reproduced with permission from [109]. Copyright John Wiley and Sons, 2019.